edited by Roderic Guigó

A Course on Sequence Analysis. Practical

Signal Searches in DNA sequences

by Roderic Guigó 6/6/97

In this practical we will run a genomic DNA sequence against a database of position weight matrices representing promoter elements, and will try to locate potential splice sites in the genomic sequence.

WWW DB Tools

We will use:

Step 1. Extract a genomic DNA sequence from the database

Step 2.Weigth matrix based search of potential promoter elements

Analyze the results and compare with the EMBL annotation for the sequence


Step 3.Multivariate Analysis based search for potential splice sites